Research Categories: Microdroplets

A diagram illustrating a chemical reaction and its analysis. The top portion shows a reaction scheme where a phenyl compound is reacted with palladium (Pd) complex in acetonitrile and hydrogen peroxide (H₂O₂), producing a carbonyl compound. The bottom section depicts a gas flow system with nitrogen (N₂) and charged particles interacting. This part includes diagrams of palladium species, highlighting various states and connections related to the reaction. Checklist items indicate that the experiment involves kinetic studies, isotope-labeling, and high-resolution mass spectrometry for analysis.

In-Situ Ambient Ionization Mass Spectrometry for Mechanistic Studies of Organometallic Catalysis

Katherine Walker High-resolution electrospray ionization mass spectrometry (ESI-MS) is an powerful technique for identifying organometallic intermediates in catalytic reactions.1-3 While identifying intermediates is not sufficient for fully understanding a mechanism, it provides one important piece of information that can be combined with traditional kinetic and isotope labeling studies to provide insights on catalytic mechanisms. Additionally, […]

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A diagram illustrating the interaction between an enzyme, substrate, and cofactor. The enzyme and substrate are represented by two parallel lines converging toward a circular shape on the right, which symbolizes a reaction site, with an arrow labeled "t" indicating movement or interaction between the components.

Biochemical Reactions in Microdroplets from a Theta Tip Capillary

Many enzymatic reactions catalyze reactants to products while populating short-lived intermediates. The development of time-resolved mass spectrometry offers high sensitivity and selectivity for studying the dynamic processes associated with the progress of the reaction in time. However, the rapid mixing of solutions during electrospray process is needed to probe the steady-state kinetics in faster processes. […]

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